Wholesale Natural Vitamin E, Mixed Tocopherols 90%; Halal & IP
Certificated; Antioxidant factors; Enhance immunity
Vitamin E was first known as an essential vitamin during a series
of studies in which administration of rancid meat products to
animals caused deficiency symptoms (later discovered to be due to
depleting bodily stores of vitamin E) which was found to be
reversed or 'cured' by wheat germ (a source of vitamin E).
Vitamin E is a term used to refer to eight molecules, which are
divided into two categories: tocopherols and tocotrienols. Each
category is further divided up into alpha (α), beta (β), gamma (γ),
and delta (δ) vitamers. And Mixed Tocopherols contains the four
|Color reaction with HNO3||Positive||USP Method|
|Retention time of main peak||Conform with the reference solution||GC|
|Percentage of d-(β+γ+δ)-Tocopherol in total Tocopherol||≥80.0%||Calculation|
|Total Plate Count||≤1,000cfu/g||USP<61>|
|Yeast & Mold||≤100cfu/g||USP<61>|
|Storage & Packaging:|
|Store in tightly closed containers at room temperature. Protected
from moisture and pest infestation.|
|◆ The items with * are tested periodically.|
Vitamin E reference plasma concentrations are in the range of
12-46µM, resulting in the recommended dietary intake being
(according to the NIH) 15mg of natural α-tocopherol or 22.4
international units (IU) for people over the age of 14 regardless
of sex. While the recommendations appear to be based exclusively
on α-tocopherol equivalents, there are differences between natural
sources providing RRR-α-tocopherol (where 15mg is recommended, as
1mg is equivalent to 1.67IU) and synthetic all-rac α-tocopherol
(where 10mg is recommended, as 1mg is equivalent to 2.22IU).
Péter S1, et al. The challenge of setting appropriate intake
recommendations for vitamin e:. Int J Vitam Nutr Res. (2013)
Vitamin E: Fact Sheet for Health Professionals.
Low density lipoproteins (LDL) are a form of cholesterol
susceptable to oxidation, as up to half the fatty acids are
polyunsaturated which are more susceptable to oxidation.
Oxidation of LDL triggers changes in its structure that make it
more conducive to form plaque in arteries. The oxidation of LDL
plays a pathological role in cardiovascular disease pertaining to
atherosclerosis, and supplements which reduce the oxidation of LDL
(such as olive leaf extract) are thought to be protective. Due to
the oxidized portions being fatty acids and vitamin E reducing
lipid peroxidation, it is thought that vitamin E (and other chain
breaking fat soluble antioxidants) play a particularly protective
role. Vitamin E is also inherently present in LDL particules
as the predominant antioxidant.
Oral supplementation of high dose vitamin E as α-tocopherol (1,000
IU) has been noted to increase the α-tocopherol content of LDL
particules in type I diabetics by 127%.
- Blood Flow and Vasorelaxation
The augmentation index (thought to reflect arterial stiffness)
appears to be improved by 5.3% in otherwise healthy males given
160mg of mixed tocotrienols daily for two months, although lower
(80mg) and higher (320mg) doses were not effective.
When looking at diabetics, high dose vitamin E as α-tocpherol
(1,600 IU) has failed to improve blood flow after eight weeks of
supplementation relative to placebo and has been implicated in
worsening blood flow mildly when continued at this dose for one
Esterbauer H, et al. Role of vitamin E in preventing the oxidation
of low-density lipoprotein. Am J Clin Nutr. (1991)
Itabe H. Oxidative modification of LDL: its pathological role in
atherosclerosis. Clin Rev Allergy Immunol. (2009)
Esterbauer H, et al. Vitamin E and other Lipophilic Antioxidants
Protect LDL against Oxidation. Eur J Lipid Sci Technol. (1989)
Skyrme-Jones RA1, et al. Vitamin E supplementation improves
endothelial function in type I diabetes mellitus: a randomized,
placebo-controlled study. J Am Coll Cardiol. (2000)
Rasool AH1, et al. Dose dependent elevation of plasma tocotrienol
levels and its effect on arterial compliance, plasma total
antioxidant status, and lipid profile in healthy humans
supplemented with tocotrienol rich vitamin E. J Nutr Sci Vitaminol
Gazis A1, et al. Effect of oral vitamin E (alpha-tocopherol)
supplementation on vascular endothelial function in Type 2 diabetes
mellitus. Diabet Med. (1999)
Economides PA1, et al. The effect of vitamin E on endothelial
function of micro- and macrocirculation and left ventricular
function in type 1 and type 2 diabetic patients. Diabetes. (2005)
ECA Healthcare Inc.
ECA (Energy Confidence Action) is a leading supplier of innovative functional ingredients for
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