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Multi Drug Rapid Test Midstream for AMP / MET / COC / OPI / THC / PCP / MTD

Categories Drug Abuse Test Kit
Brand Name: AllTest
Model Number: ILEI-402
Certification: CE
Place of Origin: CHINA
MOQ: 500
Supply Ability: 100 Million a year
Packaging Details: 40 T/Kit
Format: Cassette
Specimen: WB/S/P
Kit Size: 40 T/Kit
Cut-Off: /
Color: white
Storage: 2-30°C
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    Multi Drug Rapid Test Midstream for AMP / MET / COC / OPI / THC / PCP / MTD

    A rapid test for the simultaneous, qualitative detection of multiple drugs and drug metabolites in human saliva CE certified


    Applications:


    The Multi Drug Rapid Test Midstream for AMP /MET /COC /OPI /THC /PCP /MTD /MDMA /OXY /COT /K2 /BZO /KET /BAR /BUP /TML /6-MAM /FYL /ALC is a lateral flow chromatographic immunoassay for the qualitative detection of multiple drugs and drug metabolites in saliva at the following cut-off concentrations:

    TestCalibratorCut-off (ng/ml)
    Benzodiazepines (BZO)Oxazepam30
    Amphetamine (AMP)d-Amphetamine50
    Methamphetamine (MET)d-Methamphetamine50
    Marijuana (THC)11-nor-D9 -THC-9 COOH50
    Phencyclidine (PCP)Phencyclidine10
    Cocaine (COC)Benzoylecgonine20
    Opiates (OPI/MOP)Morphine40
    Methadone (MTD)Methadone30
    Oxycodone (OXY)Oxycodone20
    Cotinine(COT)Cotinine20
    Methylenedioxymethamphetamine(MDMA)d,l-Methylenedioxymethamphetamine50
    Synthetic Marijuana(K2)JWH -018, JWH- 07325
    Ketamine(KET)Ketamine50
    Barbiturates(BAR)Secobarbital50
    Buprenorphine (BUP)Buprenorphine10
    Tramadol(TML)Tramadol30
    6-mono-aceto-morphine (6-MAM)6-mono-aceto-morphine10
    Fentanyl(FYL)Norfentanyl50
    TestCalibratorCut-off
    Alcohol(ALC)Alcohol0.02%

    This assay provides only a preliminary analytical test result. A more specific alternate chemical method must be used in order to obtain a confirmed analytical result. Gas chromatography/mass spectrometry (GC/MS) and gas chromatography/tandem mass spectrometry (GC/MS/MS) are the preferred confirmatory methods. Professional judgment should be applied to any drug of abuse test result, particularly when preliminary positive results are indicated.


    Description:


    The Multi-Drug Rapid Test Midstream for AMP /MET /COC /OPI /THC /PCP /MTD /MDMA /OXY /COT /K2 /BZO/KET/BAR/BUP/TML/6-MAM/FYL/ALC and their metabolites is a rapid, saliva screening test that can be performed without the use of an instrument. The test utilizes monoclonal antibodies to selectively detect elevated levels of specific drugs in human saliva

    Amphetamine (AMP)

    Amphetamine is a sympathomimetic amine with therapeutic indications. The drug is often self-administered by nasal inhalation or oral ingestion. Depending on the route of administration, amphetamine can be detected in oral fluid as early as 5-10 minutes following use1. Amphetamine can be detected in oral fluids for up to 72 hours after use1.

    The amphetamine assay contained within the Multi-Drug Rapid Test Midstream yields a positive result when the amphetamine concentration in oral fluid exceeds 50ng/ml.

    Methamphetamine (MET)

    Methamphetamine is a potent stimulant chemically related to amphetamine but with greater CNS stimulation properties. The drug is often self-administered by nasal inhalation, smoking or oral ingestion. Depending on the route of administration, methamphetamine can be detected in oral fluid as early as 5-10 minutes following use1. Methamphetamine can be detected in oral fluids for up to 72 hours after use1.

    The Methamphetamine assay contained within the Multi-Drug Rapid Test Midstream yields a positive result when the methamphetamine concentration in oral fluid exceeds 50ng/ml.

    Cocaine (COC)

    Cocaine is a potent central nervous system (CNS) stimulant and a local anesthetic derived from the coca plant (erythroxylum coca). The drug is often self-administered by nasal inhalation, intravenous injection and free-base smoking. Depending on the route of administration, cocaine and metabolites benzoylecgonine and ecgonine methyl ester can be detected in oral fluid as early as 5-10 minutes following use1. Cocaine and benzoylecgonine can be detected in oral fluids for up to 24 hours after use1.

    The cocaine assay contained within the Multi-Drug Rapid Test Midstream for cocaine and opiates yields a positive result when the cocaine metabolite in oral fluid exceeds 20ng/ml.

    Opiates (OPI/MOP)


    The drug class opiates refers to any drug that is derived from the opium poppy, including naturally occurring compounds such as morphine and codeine and semi-synthetic drugs such as heroin. Opiates act to control pain by depressing the central nervous system. The drugs demonstrate addictive properties when used for sustained periods of time; symptoms of withdrawal may include sweating, shaking, nausea and irritability. Opiates can be taken orally or by injection routes including intravenous, intramuscular and subcutaneous; illegal users may also take the intravenously or by nasal inhalation. Using an immunoassay cutoff level of 40 ng/ml, codeine can be detected in the oral fluid within 1 hour following a single oral dose and can remain detectable for 7-21 hours after the dose2. Heroin metabolite 6-monoacetylmorphine (6-MAM) is found more prevalently in excreted unmetabolized, and is also the major metabolic product of codeine and heroin.

    The opiates assay contained within the Multi-Drug Rapid Test Midstream yields a positive result when the opiates concentration in oral fluid exceeds 40 ng/ml.

    Marijuana (THC)

    11-nor-D9-tetrahydrocannabinol-9-carboxylic acid (D9-THC-COOH), the metabolite of THC (D9-tetrahydrocannabinol), is detectable in saliva shortly after use. The detection of the drug is thought to be primarily due to the direct exposure of the drug to the mouth (oral and smoking administrations) and the subsequent sequestering of the drug in the buccal cavity3. Historical studies have shown a window of detection for THC in saliva of up to 14 hours after drug use3.

    The THC assay contained within the Multi-Drug Rapid Test Midstream yields a positive result when the D9-tetrahydrocannabinol concentration in oral fluid exceeds 50ng/ml.

    Phencyclidine (PCP)

    Phencyclidine, the hallucinogen commonly referred to as Angel Dust, can be detected in saliva as a result of the exchange of the drug between the circulatory system and the oral cavity. In a paired serum and saliva sample collection of 100 patients in an Emergency Department, PCP was detected in the saliva of 79 patients at levels as low as 2 ng/ml and as high as 600 ng/ml4.

    The PCP assay contained within the Multi-Drug Rapid Test Midstream yields a positive result when the PCP concentration in oral fluids exceeds 10ng/ml.

    Methadone (MTD)

    Methadone is a narcotic analgesic prescribed for the management of moderate to severe pain and for the treatment of opiate dependence (heroin, Vicodin, Percocet, morphine).

    Methadone is a long acting pain reliever producing effects that last from twelve to forty-eight hours. Ideally, methadone frees the client from the pressures of obtaining illegal heroin, from the dangers of injection, and from the emotional roller coaster that most opiates produce. Methadone, if taken for long periods and at large doses, can lead to a very long withdrawal period. The withdrawals from methadone are more prolonged and troublesome than those provoked by heroin cessation, yet the substitution and phased removal of methadone is an acceptable method of detoxification for patients and therapists.

    The MTD assay contained within the Multi-Drug Rapid Test Midstream yields a positive result when the MTD concentration in saliva exceeds 30ng/ml.

    Oxycodone (OXY)

    Oxycodone is a semi-synthetic opioid with a structural similarity to codeine. The drug is manufactured by modifying thebaine, an alkaloid found in the opium poppy. Oxycodone, like all opiate agonists, provides pain relief by acting on opioid receptors in the spinal cord, brain, and possibly directly in the affected tissues. Oxycodone is prescribed for the relief of moderate to high pain under the well-known pharmaceutical trade names of OxyContin®, Tylox®, Percodan® and Percocet®. While Tylox®, Percodan® and Percocet® contain only small doses of oxycodone hydrochloride combined with other analgesics such as acetaminophen or aspirin, OxyContin consists solely of oxycodone hydrochloride in a time-release form. Oxycodone is known to metabolize by demethylation into oxymorphone and noroxycodone.

    The OXY assay contained within the Multi-Drug Rapid Test Midstream yields a positive result when the OXY concentration in saliva exceeds 20ng/ml.

    Cotinine (COT)

    Cotinine is the first-stage metabolite of nicotine, a toxic alkaloid that produces stimulation of the autonomic ganglia and central nervous system when in humans. Nicotine is a drug to which virtually every member of a tobacco-smoking society is exposed whether through direct contact or second-hand inhalation. In addition to tobacco, nicotine is also commercially available as the active ingredient in smoking replacement therapies such as nicotine gum, transdermal patches and nasal sprays.

    Although nicotine is excreted in saliva, the relatively short half-life of the drug makes it an unreliable maker for tobacco use. Cotinine, however, demonstrates a substantially longer half-life than nicotine bears a high correlation with plasma cotinine levels and has been found to be the best maker for smoking status compared with saliva nicotine measurement, breath carbon monoxide testing and plasma thiocyanate testing. The window of detection for cotinine in saliva at a cutoff level of 20 ng/ml is expected to be up to 1-2 days after nicotine use.

    Methylenedioxymethamphetamine (MDMA)

    Methylenedioxymethamphetamine (ecstasy) is a designer drug first synthesized in 1914 by a German drug company for the treatment of obesity. Those who take the drug frequently report adverse effects, such as increased muscle tension and sweating. MDMA is not clearly a stimulant, although it has, in common with amphetamine drugs, a capacity to increase blood pressure and heart rate. MDMA does produce some perceptual changes in the form of increased sensitivity to light, difficulty in focusing, and blurred vision in some users. Its mechanism of action is thought to be via release of the neurotransmitter serotonin. MDMA may also release dopamine, although the general opinion is that this is a secondary effect of the drug (Nichols and Oberlender, 1990). The most pervasive effect of MDMA, occurring in virtually all people who took a reasonable dose of the drug, was to produce a clenching of the jaws.

    The MDMA assay contained within the Multi-Drug Rapid Test Midstream yields a positive result when the MDMA concentration in saliva exceeds 50ng/ml.

    Synthetic Marijuana (K2)

    Synthetic Marijuana or K2 is a psychoactive herbal and chemical product that, when consumed, mimics the effects of Marijuana. It is best known by the brand names K2 and Spice, both of which have largely become genericized trademarks used to refer to any synthetic Marijuana product. The studies suggest that synthetic marijuana intoxication is associated with acute psychosis, worsening of previously stable psychotic disorders, and also may have the ability to trigger a chronic (long-term) psychotic disorder among vulnerable individuals such as those with a family history of mental illness.

    Elevated levels of oral fluid/saliva metabolites are found within hours of exposure and remain detectable window up to 24-48 hours after smoking (depending on usage/dosage).

    The K2 assay contained within the Multi-Drug Rapid Test Midstream yields a positive result when the K2 concentration in saliva exceeds 20ng/ml

    Benzodiazepines (BZO)

    Benzodiazepines are medications that are frequently prescribed for the symptomatic treatment of anxiety and sleep disorders. They produce their effects via specific receptors involving a neurochemical called gamma aminobutyric acid (GABA). Because they are safer and more effective, Benzodiazepines have replaced Barbiturates in the treatment of both anxiety and insomnia. Benzodiazepines are also used as sedatives before some surgical and medical procedures, and for the treatment of seizure disorders and alcohol withdrawal. Risk of physical dependence increases if Benzodiazepines are taken regularly (e.g., daily) for more than a few months, especially at higher than normal doses. Stopping abruptly can bring on such symptoms as trouble sleeping, gastrointestinal upset, feeling unwell, loss of appetite, sweating, trembling, weakness, anxiety and changes in perception.

    The BZO assay contained within the Multi-Drug Rapid Test Midstream yields a positive result when the BZO concentration in saliva exceeds 30ng/ml.

    Ketamine (KET)

    Ketamine is a dissociative anesthetic developed in 1963 to replace PCP (Phencyclidine). While Ketamine is still used in human anesthesia and veterinary medicine, it is becoming increasingly abused as a street drug. Ketamine is molecularly similar to PCP and thus creates similar effects including numbness, loss of coordination, sense of invulnerability, muscle rigidity, aggressive / violent behavior, slurred or blocked speech, exaggerated sense of strength, and a blank stare. There is depression of respiratory function but not of the central nervous system, and cardiovascular function is maintained. The effects of Ketamine generally last 4-6 hours following use .

    The KET assay contained within the Multi-Drug Rapid Test Midstream yields a positive result when the KET concentration in saliva exceeds 50ng/ml

    Barbiturates (BAR)

    Barbiturates are CNS depressants. They are used therapeutically as sedatives, hypnotics, and anticonvulsants barbiturates are almost always taken orally as capsules or tablets. The effects resemble those of intoxication with alcohol. Chronic use of barbiturates leads to tolerance and physical dependence.

    Short-acting barbiturates taken at 400 mg/day for 2-3 months can produce a clinically significant degree of physical dependence. Withdrawal symptoms experienced during periods of drug abstinence can be severe enough to cause death.

    The approximate detection time limits for barbiturates are:

    Short acting (e.g. Secobarbital)100 mg PO (oral)4.5 days
    Long acting (e.g. Phenobarbital)400 mg PO (oral)7 days2

    The BAR assay contained within the Multi-Drug Rapid Test Midstream yields a positive result when the BAR concentration in saliva exceeds 50ng/ml.

    Buprenorphine (BUP)

    Buprenorphine is a potent analgesic often used in the treatment of opioid addiction. The drug is sold under the trade names Subutex™, Buprenex™, Temgesic™ and Suboxone™, which contain Buprenorphine HCl alone or in combination with Naloxone HCl. Therapeutically, Buprenorphine is used as a substitution treatment for opioid addicts. Substitution treatment is a form of medical care offered to opiate addicts (primarily heroin addicts) based on a similar or identical substance to the drug normally used. In substitution therapy, Buprenorphine is as effective as Methadone but demonstrates a lower level of physical dependence. The elimination half-life of buprenorphine is 20–73 hours (mean 37).Substantial abuse of Buprenorphine has also been reported in many countries where various forms of the drug are available. The drug has been diverted from legitimate channels through theft, doctor shopping, and fraudulent prescriptions, and been abused via intravenous, sublingual, intranasal and inhalation routes

    The BUP assay contained within the Multi-Drug Rapid Test Midstream yields a positive result when the BUP concentration in saliva exceeds 10ng/ml.

    Tramadol(TML)

    Tramadol(TML) is a quasi-narcotic analgesic used in the treatment of moderate to severe pain. It is a synthetic analog of codeine, but has a low binding affinity to the mu-opioid receptors. Large doses of tramadol can develop tolerance and physiological dependency and lead to its abuse. Tramadol is extensively metabolized after oral administration. Approximately 30% of the dose is excreted in oral fluid as unchanged drug, whereas 60% is excreted as metabolites. The major pathways appear to be N- and O- demethylation, glucoronidation or sulfation in the liver.

    The TML Rapid Test Midstream is a rapid oral fluid screening test that can be performed without the use of an instrument. The test utilizes a monoclonal antibody to selectively detect elevated levels of Tramadol in oral fluid. The TML Rapid Test Midstream yields a positive result when Tramadol in whole blood exceed 30 ng/ml

    6-mono-aceto-morphine (6-MAM)

    6-Monoacetylmorphine (6-MAM) or 6-acetylmorphine (6-AM) is one of three active metabolites of heroin (diacetylmorphine), the others being morphine and the much less active 3-monoacetylmorphine (3-MAM). 6-MAM is rapidly created from heroin in the body, and then is either metabolized into morphine or excreted in the oral fluid. 6-MAM remains in the oral fluid for no more than 24 hours. So a saliva specimen must be collected soon after the last heroin use, but the presence of 6-MAM guarantees that heroin was in fact used as recently as within the last day. 6-MAM is naturally found in the brain5, but in such small quantities that detection of this compound in saliva virtually guarantees that heroin has recently been consumed.

    The 6-MAM Rapid Test Midstream is a rapid saliva screening test that can be performed without the use of an instrument. The test utilizes a monoclonal antibody to selectively detect elevated levels of 6-MAM in oral fluid. The 6-MAM Rapid Test Midstream yields a positive result when 6-MAM in saliva reaches 10ng/ml. This is the suggested screening cut-off for positive specimens set by the Substance Abuse and Mental Health Services Administration (SAMHSA, USA).

    Fentanyl(FYL)

    Fentanyl, belongs to powerful narcotics analgesics, and is a special opiates receptor stimulant. Fentanyl is one of the varieties that been listed in management of United Nations “Single Convention of narcotic drug in 1961”. Among the opiates agents that under international control, fentanyl is one of the most commonly used to cure moderate to severe pain6. After continuous injection of fentanyl, the sufferer will have the performance of protracted opioid abstinence syndrome, such as ataxia and irritability etc7.8, which presents the addiction after taking fentanyl in a long time. Compared with drug addicts of amphetamine, drug addicts who take fentanyl mainly have got the possibility of higher infection rate of HIV, more dangerous injection behavior and more lifelong medication overdose9.

    The FYL Rapid Test Midstream (oral fluid) is a rapid saliva screening test that can be performed without the use of an instrument. The test utilizes a monoclonal antibody to selectively detect elevated levels of Norfentanyl in oral fluid. The FYL Rapid Test Midstream (oral fluid) yields a positive result when Norfentanyl in saliva exceeds 50ng/ml.

    Alcohol (ALC)

    Two-thirds of all adults drink alcohol10. The blood alcohol concentration at which a person becomes impaired is variable dependent upon the individual. Each individual has specific parameters that affect the level of impairment such as size, weight, eating habits and alcohol tolerance. Inappropriate consumption of alcohol can be a contributing factor to many accidents, injuries, and medical conditions

    The Multi-Drug Rapid Test Midstream yields a positive result when the concentration of Alcohol11 in saliva exceeds 0.02%


    How to use?


    Allow the test Midstream, specimen, and/or controls to reach room temperature(15-30°C) prior to testing. Instruct the donor to not place anything in the mouth including food, drink, gum or tobacco products for at least 10 minutes prior to collection.

    1. Bring the pouch to room temperature before opening it. Remove the test from the sealed pouch and use it within one hour.

    2. Take off the Midstream cap and insert the absorbent wick to the mouth .put it under the tongue to collect Saliva until the control line appears and then take out the midstream.

    3. Place the test Midstream on a clean and level surface. See illustration below.

    4. Read results at 10 minutes. Do not read results after 1 hour

    5. Read Alcohol strip result at three to Five (3-5) minutes. Compare the color of the reaction pad with the chart on foil to determine the relative saliva alcohol level.


    INTERPRETATION OF RESULTS


    (Please refer to the previous illustration)

    NEGATIVE:* Two lines appear. One colored line should be in the control region (C), and another apparent colored line adjacent should be in the test region (Drug/T). This negative result indicates that the drug concentration is below the detectable level.

    *NOTE: The shade of color in the test line region (Drug/T) will vary, but it should be considered negative whenever there is even a faint line.

    POSITIVE: One colored line appears in the control region (C). No line appears in the test region (Drug/T). This positive result indicates that the drug concentration is above the

    detectable level.

    INVALID: Control line fails to appear. Insufficient specimen volume or incorrect procedural techniques are the most likely reasons for control line failure. Review the procedure and repeat the test using a new test panel. If the problem persists, discontinue using the lot immediately and contact the manufacturer.


    QUALITY CONTROL


    A procedural control is included in the test. A colored line appearing in the control region (C) is considered an internal procedural control. It confirms sufficient specimen volume, adequate membrane wicking and correct procedural technique.

    Quality Multi Drug Rapid Test Midstream for AMP / MET / COC / OPI / THC / PCP / MTD for sale
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