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Nootropic Powder Pharmaceutical Intermediates Cdp Choline Citicoline CAS 987 78 0 For Antidepressant

Categories Pharmaceutical Intermediates
Brand Name: Simeiquan
Model Number: 2323
Certification: IOS9001
Place of Origin: China
MOQ: 1kg
Price: 10USD
Payment Terms: T/T, Western Union, MoneyGram
Supply Ability: 1000kg per month
Delivery Time: 1-3 working days
Packaging Details: 25kg carton box
CAS: 987-78-0
Name: Choline Citicoline
MF: C14H26N4O11P2
MW: 488.32
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    Nootropic Powder Pharmaceutical Intermediates Cdp Choline Citicoline CAS 987 78 0 For Antidepressant

    Product Name: CDP Choline Citicoline
    Alias: CDP-Choline
    CAS: 987-78-0
    EINECS: 213-580-7
    MF: C14H26N4O11P2
    MW: 488.32
    Purity: 99%
    Grade: Pharmaceutical Grade
    Appearance: White Powder


    Description


    CDP Choline Citicoline, also known as cytidine diphosphate-choline (CDP-Choline) or cytidine 5'-diphosphocholine is an intermediate in the generation of phosphatidylcholine from choline, a common biochemical process in cell membranes. Citicoline is naturally occurring in the cells of human and animal tissue, in particular the organs.


    CDP-choline is a nootropic compound that is essentially a prodrug for both choline and uridine, conferring both of those molecules to the body following oral ingestion of CDP-Choline. Specifically, the CDP-choline dissociates into choline and cytidine, with the cytidine then converting into uridine. CDP-choline is one of the three choline-containing phospholipids that can be orally supplemented (the other two being Alpha-GPC and phosphatidylcholine).


    This supplement is catered towards preventing or treating memory impairments associated with aging due to the fact that both of the molecules it confers are neuroprotective and potentially enhance learning. While it appears to be more effective than phosphatidylcholine (PC) at this role, in part due to also increasing PC synthesis in the brain, its potency is somewhat comparable to that of Alpha-GPC.


    Effects


    Studies suggest that CDP-choline supplements increase dopamine receptor densities, and suggest that CDP-choline supplementation helps prevent memory impairment resulting from poor environmental conditions. Preliminary research has found that citicoline supplements help improve focus and mental energy.


    Citicoline has also been shown to elevate ACTH independently from CRH levels and to amplify the release of other HPA axis hormones such as LH, FSH, GH and TSH in response to hypothalamic releasing factors. These effects on HPA hormone levels may be beneficial for some individuals but may have undesirable effects in those with medical conditions featuring ACTH or cortisol hypersecretion including PCOS, type II diabetes and major depressive disorder.


    Memory Disorders


    In a review of 14 clinical trials, the authors concluded there was evidence of benefit of citicoline on memory function and behaviour in patients suffering from cognitive deficits ranging from mild cognitive impairment to dementia. Dosing in most of the trials was 1000 mg/day. A more recent review reached the same conclusions, but went on to state that more clinical trials are needed to confirm its benefits.


    Mechanism of Action


    The neuroprotective effects exhibited by citicoline may be due to its preservation of cardiolipin and sphingomyelin, preservation of arachidonic acid content of phosphatidylcholine and phosphatidylethanolamine, partial restoration of phosphatidylcholine levels, and stimulation of glutathione synthesis and glutathione reductase activity.


    Citicoline's effects may also be explained by the reduction of phospholipase A2 activity. Citicoline increases phosphatidylcholine synthesis. The mechanism for this may be: By converting 1, 2-diacylglycerol into phosphatidylcholine, stimulating the synthesis of SAMe, which aids in membrane stabilization and reduces levels of arachidonic acid. This is especially important after an ischemia, when arachidonic acid levels are elevated.


    Dosage


    Standard dosing of CDP-choline is to take 200-600mg in two divided doses usually separated by 8-12 hours, although a single daily dose is also sometimes used. There are some properties, such as attention-promotion or improving bioenergetics, that seem to respond exclusively or more strongly to the lower dosage range. Other properties like appetite are the opposite, and thus the ideal dosage depends somewhat on the goal.


    Side Effects


    Citicoline has a very low toxicity profile in animals and humans. Clinically, doses of 2000 mg per day have been observed and approved. Minor transient adverse effects are rare and most commonly include stomach pain and diarrhea.



    Nootropics


    NameCASPurity
    CDP-Choline987-78-0≥98% HPLC
    Citicoline sodium33818-15-4≥98% HPLC
    Coluracetam (MKC-231)135463-81-9≥99.0% HPLC
    Fasoracetam110958-19-5≥99.0% HPLC
    Galantamine Hydrobromide1953-4-4≥99.0% HPLC
    Huperzine A102518-79-6≥1.0% and 99% HPLC
    Armodafinil112111-43-0≥99.0% HPLC
    adrafinils63547-13-7≥99.0% HPLC
    Hydrafinil (9-Fluorenol)1689-64-1≥99.0% HPLC
    L-Alpha glycerylphosphorylcholine/ GPC28319-77-950%, 99% HPLC
    Phosphatidylserine51446-62-9≥20%, 50% and 70% HPLC
    L-α-Phosphatidylcholine8002-43-570%, 50%
    Magnesium L-Threonate778571-57-6≥95.0% Titration
    N-Acetyl-L-Tyrosine537-55-398%~102% HPLC
    Noopept157115-85-0≥99.0% HPLC
    Oxiracetam62613-82-5≥99.0% HPLC
    Phenibut1078-21-3≥99.0% HPLC
    Phenylpiracetam77472-70-9≥99% HPLC
    Pikamilone (Sodium)62936-56-5≥98%~101%Titration
    Piracetam7491-74-9≥99.0% HPLC
    Pramiracetam68497-62-1≥98.0~102.0% HPLC
    Sulbutiamine3286-46-2≥98.0% HPLC
    Sunifiram314728-85-3≥99.5% HPLC
    Tianeptine Hemisukfate Monohydrate,tianeptine sulfate66981-73-5≥98.0%~102.0% HPLC
    Tianeptine sodium30123-17-2≥99.0% HPLC
    Vincamine1617-90-9≥99.0% HPLC
    Vinpocetine42971-09-5≥99.0% HPLC
    PRL-8-5351352-87-5≥99.0% HPLC
    NSI-1891270138-40-3≥99.0% HPLC
    IDRA-2122503-72-6≥99.0% HPLC
    Mexidol127464-43-1≥99.0% HPLC
    agomelatine138112-76-2≥99.0% HPLC
    5a hydroxy laxogenin56786-63-1≥99.0% HPLC
    tadanafil171596-29-5≥99.0% HPLC
    avanafil330784-47-9≥99.0% HPLC

    4. Specification:

    NameSpecification
    MGF2mg/vials, 10 vials/box
    PEG MGF2mg/vials, 10 vials/box
    CJC-1295 with DAC2mg/vials, 10 vials/box
    CJC-1295 without DAC2mg/vials, 10 vials/box
    PT-14110mg/vials, 10 vials/box
    MT-110mg/vials, 10 vials/box
    MT-210mg/vials, 10 vials/box
    GHRP-25mg/vials, 10 vials/box
    GHRP-210mg/vials, 10 vials/box
    GHRP-65mg/vials, 10 vials/box
    GHRP-610mg/vials, 10 vials/box
    Ipamorelin2mg/vials, 10 vials/box
    Hexarelin2mg/vials, 10 vials/box
    Sermorelin2mg/vials, 10 vials/box
    Oxytocin2mg/vials, 10 vials/box
    TB5002mg/vials, 10 vials/box
    pentadecapeptide BPC 1572mg/vials, 10 vials/box
    Hg 176-1912mg/vials, 10 vials/box
    Triptorelin2mg/vials, 10 vials/box
    Tesamorelin2mg/vials, 10 vials/box
    Gonadorelin2mg/vials, 10 vials/box
    Gonadorelin10mg/vials, 10 vials/box
    DSIP2mg/vials, 10 vials/box
    Selank5mg/vials, 10 vials/box

    NameSpecification
    MGF2mg/vial
    PEG MGF2mg/vial
    CJC-1295 with DAC2mg/vial
    CJC-1295 without DAC2mg/vial
    PT-14110mg/vial
    MT-1(Melanotan)10mg/vial
    MT-210mg/vial
    GHRP-25mg/vial
    GHRP-210mg/vial
    GHRP-65mg/vial
    GHRP-610mg/vial
    Ipamorelin2mg/vial
    Hexarelin2mg/vial
    Sermorelin2mg/vial
    Oxytocin2mg/vial
    TB5002mg/vial
    pentadecapeptide BPC 1572mg/vial
    176-1912mg/vial
    Triptorelin2mg/vial
    Tesamorelin2mg/vial
    Gonadorelin2mg/vial
    Gonadorelin10mg/vial
    DSIP2mg/vial
    Selank5mg/vial

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    CAS: 23964-57-0Articaine hydrochloride



    Growth Hormne Peptides

    T-A001MGF2mg
    T-A002PEG MGF2mg
    T-A003CJC-1295 with DAC2mg
    T-A004CJC-1295 without DAC2mg
    T-A005PT-14110mg
    T-A006MT-1(Melanotan-1)10mg
    T-A007MT-2(Melanotan-2)10mg
    T-A008GHRP-25mg
    T-A008GHRP-210mg
    T-A009GHRP-65mg
    T-A009GHRP-610mg
    T-A0010Ipamorelin2mg
    T-A0011Hexarelin2mg
    T-A0012Sermorelin2mg
    T-A0013Oxytocin1g
    T-A0014TB5002mg
    T-A0015pentadecapeptide BPC 1572mg
    T-A00162mg
    T-A0017Triptorelin2mg
    T-A0018Tesamorelin2mg
    T-A0020Gonadorelin2mg
    T-A0020Gonadorelin10mg
    T-A0021DSIP2mg
    T-A0022Selank5mg
    T-A0023Epitalon10mg



    PeptidesSpecification
    MGF2mg
    PEG MGF2mg
    CJC-1295 with DAC2mg
    CJC-1295 without DAC2mg
    PT-14110mg
    MT-110mg
    MT-210mg
    GHRP-25mg
    GHRP-210mg
    GHRP-65mg
    GHRP-610mg
    Ipamorelin2mg
    Hexarelin2mg
    Sermorelin2mg
    Oxytocin2mg
    TB5002mg
    Pentadecapeptide BPC 1572mg
    Triptorelin2mg
    Tesamorelin2mg
    Gonadorelin2mg
    Gonadorelin10mg
    DSIP2mg
    Selank5mg




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    -------------------------------- Additional Information -------------------------------
    Place of origin : China
    Brand : SMQ
    Certificate : ISO9001:2008, KOSHER, GMP, SGS
    Production capacity : 1000 Kilograms/Month

    -------------------------------- Delivery Information ---------------------------------
    Packing : Foil bag/tin or as your request
    Payment : T/T, Western Union, MoneyGram
    Port : Shanghai, Shenzhen, Hongkong
    Shipment method : EMS, DHL, FeDex, UPS, etc
    Leading time : Within 24 hours after payment
    Delivery time : Within 6 business days after payment (door to door service)
    -------------------------------- Our Competitive Advantages ---------------------------
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    3. You confirm the order and pay money 100% in advance and send us the detailed address.
    4.We will pack your parcel and arrange to shipment according to your requirements
    5.Once parcel is sent,I will offer you parcel's picture,tracking number and tracking website.
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