Catalog No.: CL1230
Product Name: Lycopene(powder) CAS No.:502-65-8
Molecular Formula: C40H56
Molecular Weight: 536.88
Appearance: Red to reddish brown crystal or Dark red powder
Solubility: Insoluble in water.
Assay: 3% ,5%,6%,10%,30%(HPLC), or >96%
Storage:Keep in cool and dry place.
Description: Antioxidant micronutrient of tomatoes associated with decreased
risk for cancer and cardiovascular disease. Enhances gap juction
communication between cells via upregulation of connexin 43 and
reduces proliferation of cancer cells in culture. Inhibits
cholesterol synthesis and enhances low-density lipoprotein
Lycopene is a bright red carotene and carotenoid pigment and
phytochemical found in tomatoes and other red fruits &
vegetables, such as red carrots, watermelons and papayas (but not
strawberries or cherries). Although lycopene is chemically a
carotene, it has no vitamin A activity.
In plants, algae, and other photosynthetic organisms, lycopene is
an important intermediate in the biosynthesis of many carotenoids,
including beta carotene, responsible for yellow, orange or red
pigmentation, photosynthesis, and photo-protection. Like all
carotenoids, lycopene is a polyunsaturated hydrocarbon (an
unsubstituted alkene). Structurally, it is a tetraterpene assembled
from eight isoprene units, composed entirely of carbon and
hydrogen, and is insoluble in water. Lycopenes eleven conjugated
double bonds give it its deep red color and are responsible for its
antioxidant activity. Due to its strong color and non-toxicity,
lycopene is a useful food coloring.
Lycopene is not an essential nutrient for humans, but is commonly
found in the diet, mainly from dishes prepared with tomato sauce.
When absorbed from the stomach, lycopene is transported in the
blood by various lipoproteins and accumulates in the liver, adrenal
glands, and testes.
Because preliminary research has shown an inverse correlation
between consumption of tomatoes and cancer risk, lycopene has been
considered a potential agent for prevention of some types of
cancers, particularly prostate cancer. However, this area of
research and the relationship with prostate cancer have been deemed
insufficient of evidence for health claim approval by the US Food
and Drug Administration .
Structure and physical properties:
Lycopene is a symmetrical tetraterpene assembled from 8 isoprene
units. It is a member of the carotenoid family of compounds, and
because it consists entirely of carbon and hydrogen, is also a
carotene.Isolation procedures for lycopene were first reported in
1910, and the structure of the molecule was determined by 1931. In
its natural, all-trans form, the molecule is long and straight,
constrained by its system of eleven conjugated double bonds. Each
double bond in this extended electron system reduces the energy
required for electrons to transition to higher energy states,
allowing the molecule to absorb visible light of progressively
longer wavelengths. Lycopene absorbs all but the longest
wavelengths of visible light, so it appears red.
Plants and photosynthetic bacteria naturally produce all-trans
lycopene, but a total of 72 geometric isomers of the molecule are
sterically possible.When exposed to light or heat, lycopene can
undergo isomerization to any of a number of these cis-isomers,
which have a bent rather than linear shape. Different isomeres were
shown to have different stabilities due to their molecular energy
(highest stability: 5-cisall-trans9-cis13-cis > 15-cis >
7-cis > 11-cis: lowest). In the human bloodstream, various
cis-isomers constitute more than 60% of the total lycopene
concentration, but the biological effects of individual isomers
have not been investigated.
Lycopene is insoluble in water, and can be dissolved only in
organic solvents and oils. Because of its non-polarity, lycopen